All uPAR reagents are produced in house and quality controlled, including 18 uPAR Antibody, 2 uPAR ELISA, 24 uPAR Gene, 1 uPAR IPKit, 3 uPAR Lysate, 3 uPAR Protein, 2 uPAR qPCR. All uPAR reagents are ready to use.
Recombinant uPAR proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His.
uPARantibodies are validated with different applications, which are FCM, ELISA, ELISA(Cap), IP, IHC-P, ELISA(Det).
uPARcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each uPAR of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
uPARELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. uPAR and uPA levels in both resected tumor tissue and plasma are of independent prognostic significance for patient survival in several types of human cancer. This system has classically been thought to drive tumor progression by mediating directed extracellular proteolysis on the surface of migrating or invading cells, and intervening with this proteolysis by targeting uPAR has been proposed to represent a novel approach for inhibiting tumor progression. uPAR, also known as PLAUR or CD87, has been implicated in the growth, metastasis, and angiogenesis of several solid and hemotologic malignancies. uPAR is a highly glycosylated, 55-60kDa integral membrane protein linked to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor. It is part of a cell surface system that also consists of the serine protease uPA and several specific inhibitors (plasminogen activator inhibitors 1 and 2). Additionally, the analysis of CD87 (urokinase-type plasminogen activator receptor - uPAR) expression has a potential role in the diagnostic or prognostic work-up of several hematological malignancies, particularly acute leukemia and multiple myeloma.