All OX40 reagents are produced in house and quality controlled, including 6 OX40 Antibody, 48 OX40 Gene, 1 OX40 IPKit, 9 OX40 Lysate, 9 OX40 Protein, 2 OX40 qPCR. All OX40 reagents are ready to use.
Recombinant OX40 proteins are expressed by HEK293 Cells with fusion tags as C-rabbit IgG-Fc, C-cleavage, C-human IgG1-Fc, C-human IgG1-Fc & His, C-His.
OX40antibodies are validated with different applications, which are ELISA, WB, IP.
OX40cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each OX40 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an existing state of tolerance in malignancies, leading to a reactivation of antitumor immunity. The interaction between OX40 and OX40L plays an important role in antigen-specific T-cell expansion and survival. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, natural killer cells, and natural killer T cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40-OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases, making them attractive candidates for intervention in the clinic. Conversely, stimulating OX40 has shown it to be a candidate for therapeutic immunization strategies for cancer and infectious disease.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets