All N Cadherin reagents are produced in house and quality controlled, including 11 N Cadherin Antibody, 27 N Cadherin Gene, 4 N Cadherin Lysate, 4 N Cadherin Protein, 3 N Cadherin qPCR. All N Cadherin reagents are ready to use.
Recombinant N Cadherin proteins are expressed by Baculovirus-Insect Cells, HEK293 Cells with fusion tags as C-His, C-cleavage, C-human IgG1-Fc & His.
N Cadherinantibodies are validated with different applications, which are FCM, ELISA, ICC/IF, IF, WB.
N CadherincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each N Cadherin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
Cadherins are calcium dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass tranmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression.