All CD18 reagents are produced in house and quality controlled, including 1 CD18 Antibody, 36 CD18 Gene, 2 CD18 qPCR. All CD18 reagents are ready to use.
CD18antibodies are validated with different applications, which are IHC-P, ICC/IF, IF.
CD18cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CD18 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Integrins form a family of heterodimeric transmembrane receptors that regulate cell–adhesion and cell-extracellular matrix interactions. Lymphocyte function-associated antigen 1 (LFA-1, αLβ2) is a leukocyte specific integrin that mediates firm arrest of leukocytes on the endothelium during migration and establishes cell-cell contacts such as the immunological synapse between DCs and T cells. At the molecular level, transient modifications of adhesion are accomplished by conformational changes of LFA-1 from a bent down inactive to an upright active conformation with an open headpiece, leading to low- and high-affinity for its major ligand ICAM-1 respectively.