All IL21 reagents are produced in house and quality controlled, including 12 IL21 Antibody, 60 IL21 Gene, 1 IL21 Lysate, 5 IL21 Protein, 3 IL21 qPCR. All IL21 reagents are ready to use.
Recombinant IL21 proteins are expressed by E. coli, Baculovirus-Insect Cells with fusion tags as Native, C-His.
IL21antibodies are validated with different applications, which are ELISA, WB.
IL21cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL21 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. IL21 is expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. It may promote the transition between innate and adaptive immunity. IL-21 has been tried as therapy for alleviating allergic responses. It can significantly decrease pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation)