All IL11 reagents are produced in house and quality controlled, including 2 IL11 Antibody, 36 IL11 Gene, 2 IL11 Protein, 3 IL11 qPCR. All IL11 reagents are ready to use.
Recombinant IL11 proteins are expressed by E. coli with fusion tags as N-cleavage.
IL11antibodies are validated with different applications, which are ELISA.
IL11cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IL11 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.