All ICAM-1 reagents are produced in house and quality controlled, including 32 ICAM-1 Antibody, 4 ICAM-1 ELISA, 48 ICAM-1 Gene, 2 ICAM-1 IPKit, 8 ICAM-1 Lysate, 8 ICAM-1 Protein, 3 ICAM-1 qPCR. All ICAM-1 reagents are ready to use.
Recombinant ICAM-1 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-cleavage, C-human IgG1-Fc & His, C-human IgG1-Fc.
ICAM-1antibodies are validated with different applications, which are ELISA, ELISA(Cap), FCM, ICC/IF, IF, WB, IHC-P, IP, ELISA(Det).
ICAM-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ICAM-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ICAM-1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.