All FZD1 reagents are produced in house and quality controlled, including 4 FZD1 Antibody, 24 FZD1 Gene, 1 FZD1 Lysate, 1 FZD1 Protein, 2 FZD1 qPCR. All FZD1 reagents are ready to use.
Recombinant FZD1 proteins are expressed by HEK293 Cells with fusion tags as C-His.
FZD1antibodies are validated with different applications, which are ELISA, IHC-P.
FZD1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each FZD1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Frizzled-1, also known as FZD1, belongs to the G-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, Frizzled leads to activation of Dishevelled in the cytosol. Frizzled proteins and the genes encoding them have been identified in an array of animals, from sponges to humans. Frizzled proteins play key roles in governing cell polarity, embryonic development, formation of neural synapses, cell proliferation, and many other processes in developing and adult organisms. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.