All Fc epsilon RI reagents are produced in house and quality controlled, including 1 Fc epsilon RI Antibody, 24 Fc epsilon RI Gene, 3 Fc epsilon RI Lysate, 3 Fc epsilon RI Protein, 2 Fc epsilon RI qPCR. All Fc epsilon RI reagents are ready to use.
Recombinant Fc epsilon RI proteins are expressed by HEK293 Cells with fusion tags as C-His, Native, C-human IgG1-Fc.
Fc epsilon RIantibodies are validated with different applications, which are WB, ELISA, ICC/IF, IF.
Fc epsilon RIcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Fc epsilon RI of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.