All Caspase-14 reagents are produced in house and quality controlled, including 13 Caspase-14 Antibody, 28 Caspase-14 Gene, 1 Caspase-14 Protein, 2 Caspase-14 qPCR. All Caspase-14 reagents are ready to use.
Recombinant Caspase-14 proteins are expressed by E. coli with fusion tags as N-His.
Caspase-14antibodies are validated with different applications, which are FCM, ELISA, ICC/IF, IF, IHC-P.
Caspase-14cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Caspase-14 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Caspase 14 is a member of the caspase family. Caspases are a kind of cysteine proteinase consisting of a prodomain plus large and small catalytic subunits, that play a central role in cell apoptosis. Caspase 14 possesses an unusually short prodomain and is highly expressed in embryonic tissues but absent from most of the adult tissues except for the skin, which suggests a role in ontogenesis and skin physiology. Unlike the other short prodomain caspases(caspase-3, caspase-6, and caspase-7), Caspase 14 was not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapaptotic members of the bcl-2 family. Caspase 14 has been described to be processed and activated by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may take part in keratinocyte terminal differentiation, which is essential for the skin barrier.