All IP-10 reagents are produced in house and quality controlled, including 3 IP-10 Antibody, 37 IP-10 Gene, 3 IP-10 Protein, 3 IP-10 qPCR. All IP-10 reagents are ready to use.
Recombinant IP-10 proteins are expressed by Yeast, E. coli with fusion tags as C-His, Native.
IP-10antibodies are validated with different applications, which are ELISA.
IP-10cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each IP-10 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.