All BCAM reagents are produced in house and quality controlled, including 7 BCAM Antibody, 2 BCAM ELISA, 36 BCAM Gene, 1 BCAM IPKit, 5 BCAM Lysate, 5 BCAM Protein, 3 BCAM qPCR. All BCAM reagents are ready to use.
Recombinant BCAM proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
BCAMantibodies are validated with different applications, which are ELISA, IHC-P, ELISA(Det), WB, IP, ELISA(Cap).
BCAMcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each BCAM of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
BCAMELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.