All PD-L2 reagents are produced in house and quality controlled, including 10 PD-L2 Antibody, 1 PD-L2 ELISA, 48 PD-L2 Gene, 10 PD-L2 Lysate, 10 PD-L2 Protein, 3 PD-L2 qPCR. All PD-L2 reagents are ready to use.
Recombinant PD-L2 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-human IgG1-Fc & His, C-His.
PD-L2antibodies are validated with different applications, which are ELISA, IHC-P, FCM, WB, ELISA(Cap).
PD-L2cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each PD-L2 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
PD-L2ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Expression host: HEK293 Cells
Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
Immune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets